Chemoprevention in patients with genetic risk of colorectal cancers.

Hereditary Nonpolyposis Colorectal Cancer (HNPCC)/Lynch Syndrome: Surveillance and Diagnostic strategies

Introduction: Hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) is an autosomal dominant genetic disease. The disease is caused by a mutation in one of four genes of the DNA mismatch repair system and increases the risk for various cancers, especially the uterine and colon cancers. The prevalence of this disease in the general population is about 1 in 500 and it causes about 2-3...

Association of interleukin-1 gene polymorphism with risk of gastric and colorectal cancers in an Iranian population

Women with HNPCC: a target population for the chemoprevention of gynecologic cancers.

Hereditary nonpolyposis colorectal cancer syndrome (HNPCC) is an autosomal-dominant inherited cancer susceptibility syndrome that is associated with increased risk of development of endometrial and ovarian cancers. Therefore, women with HNPCC are candidates for chemoprevention of gynecological cancers. Although there have been a number of clinical trials examining chemoprevention strategies for...

شاخص های اپیدمیولوژیک و کلینیکو پاتولوژیک سرطانهای کولورکتال در ساری 1386-1378

Background and Purpose: Each year, about 50,000 new cases of cancer occur in Iran and the most common being the gastrointestinal (GI) tract (38%). Colorectal cancers account for the 3rd and 4th most prevalent cancers in Iranian men and women, respectively. Since genetic and environmental factors lead to differences in colorectal cancer occurrence in different geographic regions and races, we ...

Society of Gynecologic Oncology statement on risk assessment for inherited gynecologic cancer predispositions.

Women with germline mutations in the cancer susceptibility genes, BRCA1 or BRCA2, associated with Hereditary Breast & Ovarian Cancer syndrome, have up to an 85% lifetime risk of breast cancer and up to a 46% lifetime risk of ovarian, tubal, and peritoneal cancers. Similarly, women with mutations in the DNA mismatch repair genes, MLH1, MSH2, MSH6, or PMS2, associated with the Lynch/Hereditary No...